. Author manuscript; available in PMC: 2017 Dec 20.

Published in final edited form as: Expert Rev Precis Med Drug Dev. 2016 Dec 20;1(6):487–495. doi: 10.1080/23808993.2016.1269600

Table 3.

Asthma exacerbation genes identified by gene-environment interaction studies

	Gene	Chromosome Location	SNP(s)	Population(s)	HGVS Name	Reference
1	ST13	22q13.2	rs138335 rs138337	Netherlands (Caucasians), UK^a (Caucasians)	NC_000022.10:g.41227086C>G NC_000022.10:g.41231053A>G	[55]
2	FCER2	19p13.3	rs28364072	US^b (Caucasians and African Americans); Netherlands and UK (Caucasians)	NC_000019.10:g.7690399A>G	[57, 58]
3	P2RX7	12q24	rs2230911	US (African Americans)	NC_000012.11:g.121615131C>G	[61]
4	CMTR1	6p21.1	rs2395672	US (Caucasians)	NC_000006.12:g.37460801G>A	[63]
6	ALOX5	10q11.2	repeat variant	US (Caucasians)	N/A	[65]
7	LTA4H	12q22	rs2660845	US (Caucasians)	NC_000012.12:g.96044775G>A	[65]
8	LTC4S	5q35	rs730012	US (Caucasians)	NC_000005.10:g.179793637A>C	[65]

United Kingdom

United States