Skip to main content
. Author manuscript; available in PMC: 2018 May 8.
Published in final edited form as: Organometallics. 2017 Feb 1;36(9):1673–1676. doi: 10.1021/acs.organomet.6b00888

Table 1.

Inhibition of compounds 2–7 on PBP and β-lactamases.

IC50 μM
Enzyme 1 2 3 4 5 6 7 penicillin G
DD-carboxypeptidase 64-575 176 ± 2.38 0.158 ± 0.002 0.052 ± 0.001 0.133 ± 0.002 0.027 ± 0.000 0.083 ± 0.003 0.081 0.003 ± 0.153 ± 0.002
CTX-M-14 1620 ± 144 31 ± 5 44 ± 4 716 ± 108 7 ± 1 36 ± 4 363 ± 49 nd*
B. cereus 569/H9 4661 ± 422 142 ± 28 200 ± 25 82 ± 12 117 10 ± 126 ± 27 65 ± 5 nd
*

nd, not determined.