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Generation of IL-21–producing Tfh17 cells is CD275 dependent. (A) Splenic MNCs were gated on Th17 cells, and levels of IL-21 were plotted against CXCR5. (B) Scatter plots of cell frequency (left panel) and number (right panel) of IL-21+ CXCR5+ Th17 cells from individual 12- to 16-wk-old Rasgpr1+/− (●), Rasgrp1−/− (○), ICOSL/CD275−/− (▴), and DKO (∇) mice (one-way ANOVA with Tukey’s multiple-comparison test, *p < 0.01).
