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. Author manuscript; available in PMC: 2017 Oct 16.
Published in final edited form as: J Immunol. 2016 May 16;196(12):4935–4946. doi: 10.4049/jimmunol.1402193

FIGURE 8.

FIGURE 8

Frequency of Tregs in Rasgrp1-deficient mice with and without CD275 and CD25 levels on Th1 and Th17 cells. Tregs were identified as CD4+ CD25+ Foxp3+ cells. (A) Frequency of Tregs in 12- to 16-wk-old Rasgpr1+/− (filled black bar), Rasgrp1−/− (filled gray), ICOSL/CD275−/− (open black), and DKO (open gray) mice. Data are mean 6 SD from 5–10 mice per group (one-way ANOVA with Tukey’s multiple-comparison test, *p < 0.01). (B) CD25 levels on Th1 and Th17 cells from Rasgrp1−/− mice. (C) Summary of CD25-positive Th1 and Th17 cells from spleens of 12- to 16-wk-old control and Rasgrp1−/− mice (one-way ANOVA with Tukey’s multiple-comparison test, *p < 0.01, **p < 0.001).