Table 1.
Development of MCI and dementia from time of PD diagnosis: longitudinal studies
| Study | N | Duration (years) |
MCI at baseline (%) |
MCI at follow-up (%) |
Dementia during study (%) |
Comments | MCI and risk of dementia |
Refs |
|---|---|---|---|---|---|---|---|---|
| Pigott, K. et al. (2015) | 141 | 4.4 | 0 | 47.4* | 28 | Normal cognition at baseline | – | 10 |
| PARKWEST: Pedersen, K. F. et al. (2013) | 182 | 5 | 20.3 | – | 19.2 | – | RR 39.2, P < 0.001 | 6 |
| Amsterdam: Broeders, M. et al. (2013) | 123 | 5 | 35 | 50‡ | 13.8 | – | “All patients who progressed to PD dementia had MCI at a previous assessment” | 213 |
| PPMI: Weintraub, D et al. (unpublished work) | 423 | 3 | 10 | 15–21§ | 3–6§ | – | – | – |
| CamPaIGN: Williams-Gray, C. H. et al. (2013) | 142 | 10 | 364 | 62 at 3 years‖ | 46 (17 at 5years) | – | Reduced semantic fluency (HR 3.05) and pentagon copying (HR 2.55) | 8 |
| Napoli: Santangelo, G. et al. (2015) | 76 | 4 | 32.9 | 38.2 | 5.4 | 50% MCI at 4 years | – | 9 |
| NYPUM: Domellöf, M. E. et al. (2015) | 147 | 5 | 42.6 | – | 27.6 | – | MCI at baseline: 6.5 × increased risk of dementia | 214 |
| Sydney: Hely, M. A. et al. (2008) | 136 | 20 | – | – | 83 | MCI criteria not available at study start | – | 215 |
*
Any cognitive impairment.
‡
Of those without dementia.
§
Using different criteria.
‖
Cognitive impairment rather than MCI. MCI, mild cognitive impairment; N, number of participants; PD, Parkinson disease.