Figure 1.

Effect of 9-phenanthrol on glucose-stimulated insulin secretion from isolated rat islets of Langerhans. Insulin secretion was studied in batch incubations where groups of three islets were incubated for 1 hour in 3.3 mM or 10 mM glucose in the presence of different concentrations of 9-phenanthrol, as indicated at the bottom of the figure. In (a), insulin secretion is expressed as μU/islet/hour and in (b), insulin secretion is expressed as percent of total insulin content per hour. ^∗P ≤ 0.05, ^∗∗P ≤ 0.01, and ^∗∗∗P ≤ 0.001 (one-way ANOVA).