Table 2. Factors associated with positive anti-HAV antibody in the 2012–2016 cohort.
| Anti-HAV antibody | Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
| Negative(n = 2255) | Positive(n = 605) | OR | 95% CI | p | OR | 95% CI | P | |
| Age, mean ± SD, years | 31.1 ± 8.0 | 39.3 ± 10.8 | - | - | <0.01 | 1.13 | 1.11–1.15 | <0.01 |
| Male sex, n (%) | 2171 (96.3) | 559 (92.4) | 0.47 | 0.32–0.68 | <0.01 | 0.59 | 0.28–1.23 | 0.29 |
| CD4, mean ± SD, cells/μl | 287.1 ± 188.0 | 277.6 ± 199.5 | - | - | 0.28 | - | - | - |
| Plasma HIV RNA load, mean ± SD, log10 copies/ml | 4.8 ± 0.8 | 4.7 ± 0.8 | - | - | 0.01 | 0.95 | 0.83–1.09 | 0.46 |
| Residence in Taiwan, n (%) | <0.01 | |||||||
| Northern | 1579 (70.0) | 434 (71.7) | Referent | Referent | ||||
| Central | 216 (9.6) | 100 (16.5) | 1.68 | 1.30–2.18 | <0.01 | 0.75 | 0.48–1.16 | 0.19 |
| Southern | 460 (20.4) | 71 (11.7) | 0.56 | 0.43–0.74 | <0.01 | 0.49 | 0.34–0.72 | <0.01 |
| Risk group, n (%) | <0.01 | |||||||
| MSM | 1857 (82.3) | 372 (61.5) | Referent | Referent | ||||
| Heterosexuals | 104 (4.6) | 62 (10.2) | 2.94 | 2.35–3.68 | <0.01 | 1.49 | 0.83–2.66 | 0.18 |
| IDUs | 275 (12.2) | 162 (26.8) | 2.98 | 2.13–4.15 | <0.01 | 1.44 | 0.75–2.75 | 0.27 |
| Others | 19 (0.8) | 9 (1.5) | 2.37 | 1.06–5.27 | 0.03 | 2.861 | 0.76–10.85 | 0.12 |
| HBV infectiona, n (%) | 427/1559 (27.4) | 220/371 (59.3) | 3.86 | 3.05–4.89 | <0.01 | 1.44 | 1.08–1.93 | 0.01 |
| Anti-HBs-positive, n (%) | 864/1652 (52.3) | 219/399 (54.9) | 1.11 | 0.89–1.38 | 0.35 | - | - | - |
| Anti-HCV-positive, n (%) | 325/2249 (14.5) | 186/600 (31.0) | 2.66 | 2.16–3.28 | <0.01 | 1.523 | 0.90–2.59 | 0.12 |
| RPR-positive, n (%) | 404/1622 (24.9) | 87/391 (22.3) | 0.86 | 0.66–1.12 | 0.27 | - | - | - |
Abbreviations: 95% CI, 95% confidence interval; anti-HAV, anti-hepatitis A virus; anti-HBs, anti-hepatitis B surface; anti-HBc, anti-hepatitis B core; anti-HCV, anti-hepatitis C virus; HBsAg, hepatitis B surface antigen; IDUs, injecting drug users; MSM, men who have sex with men; OR, odds ratio; RPR, rapid plasma reagin; SD, standard deviation.
aHBV infection indicates presence of either HBsAg, anti-HBc or both.