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. 2017 Sep 15;51(5):1449–1459. doi: 10.3892/ijo.2017.4126

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Copyright: © Liao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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HBx activates the Notch1 pathway and DAPT attenuates cell growth via inhibition of ERK and AKT pathways. HBx gene (A) and protein (B) were expressed in HepG2.2.15 cells. (B) The Notch1 pathway was activated in HepG2.2.15. (C) HBx was knocked down by SiRNA and its mRNA level was tested by qRT-PCR. The changes were presented as fold change in comparison to the control. (D) The Notch1 pathway was inhibited after SiHBx. (E) Cell proliferation of HepG2.2.15 cells was inhibited after SiHBx. (F) Cell proliferation of HepG2.2.15 cells was inhibited after DAPT treatment. (G) Alteration of expression of the Notch1 pathway after DAPT treatment. (H) Expressions of pERK and pAKT were decreased after DAPT treatment. (I and J) Expression of DUSP1 and PTEN was increased after DAPT treatment. Data were collected in at least three independent experiments. ^**P<0.01, ^***P<0.001; NS, not significant.