Table 2. Follow-up characteristics of the patients by AD subtype.
| Minimal-atrophy n = 16, 13.0% | Limbic-predominant n = 29, 23.6% | Hippocampal-sparing n = 19, 15.4% | Typical AD n = 59, 48.0% | p* | p** | |
|---|---|---|---|---|---|---|
| MMSE follow-up | 17.9 (7.1) | 20.0 (5.0) | 19.0 (4.5) | 16.8 (7.0) | 0.587 | 0.965 |
| MMSE annual change | -1.3 (2.4) | -1.6 (2.2) | -1.7 (2.1) | -2.8 (3.0) | 0.093 | 0.209 |
| Delayed recall follow-up | 0.7 (1.4) | 0.5 (0.8) | 1.4 (2.1) | 0.3 (0.6) | 0.316 | 0.572 |
| Delayed recall annual change | -0.50 (0.98) | -0.53 (0.84) | 0.02 (0.79) | -0.23 (0.55) | 0.304 | 0.249 |
| Phonemic fluency follow-up | 22.1 (14.1) | 22.9 (10.8) | 25.8 (15.5) | 17.9 (15.9) | 0.371 | 0.700 |
| Phonemic fluency annual change | -4.6 (6.9) | -5.3 (3.1) | -0.7 (3.7) | -2.7 (6.3) | 0.567 | 0.510 |
| CDR-SB follow-up | 9.1 (3.4) | 8.4 (4.1) | 9.4 (4.4) | 9.5 (3.7) | 0.662 | 0.887 |
| CDR-SB annual change | 2.5 (1.9) | 1.9 (2.2) | 2.3 (2.2) | 2.1 (2.0) | 0.512 | 0.472 |
| CDR score follow-up | 1.5 (0.5) | 1.3 (0.7) | 1.6 (0.8) | 1.6 (0.7) | 0.663 | 0.921 |
| CDR score annual change | 0.41 (0.30) | 0.29 (0.39) | 0.36 (0.38) | 0.36 (0.40) | 0.662 | 0.524 |
All measures reported as mean (SD). “Annual change” calculated as change between follow-up assessment (17–34 months) and baseline assessment, per year.
*Minimal-atrophy—Typical AD, t-test.
** Minimal-atrophy—All other AD subtypes, t-test.
MMSE Mini-mental State Examination, CDR-SB Clinical Dementia Rating scale sum of boxes.