Figure 9.

The effect of curcumin administration on the ERK 1/2 levels in the brain. In the hippocampus, ERK 1/2 level was significantly lower in the curcumin group as compared to control (p < 0.001). Diazepam administration significantly increased the ERK 1/2 protein as compared to curcumin (p < 0.001). Diazepam and curcumin administration diminished the ERK 1/2 level (p < 0.001). In the frontal lobe, diazepam and curcumin treatment stimulated the ERK 1/2 activation (p < 0.01). Each group consisted of 10 rats. Results are expressed as mean ± SEM. ^##p < 0.01 as compared with DZP + CMC; and ^∗∗∗p < 0.001 as compared with control/CUR + CMC.