Table 1. Resulting parameters of the simulations (mean and 95% BCI1) parameters of the mean infection and of the prevalence of S. mansoni and hookworm in Azaguié, Zouatta, and Fagnampleu in Côte d’Ivoire.
Observed prevalence is the ratio of positively tested individuals in the original study, observed mean infection the arithmetic mean egg count of the individuals with a positive test.
| S. mansoni | Hookworm | |||||
|---|---|---|---|---|---|---|
| Parameters | Azaguié | Zouatta | Fagnampleu | Azaguié | Zouatta | Fagnampleu |
| (N = 500, k = 2)2 | (N = 559, k = 3) | (N = 354, k = 4) | (N = 500, k = 2) | (N = 559, k = 3) | (N = 354, k = 4) | |
| Observed prevalence (%) | 35.6 (31.4, 39.8) | 40.8 (36.7, 44.9) | 76.3 (71.8, 80.5) | 11.4 (8.6, 14.2) | 35.4 (31.5, 39.4) | 59.0 (53.9, 64.1) |
| Estimated ‘true’ prevalence (%) | 49.3 (40.4, 61.2) | 59.6 (50.7, 69.3) | 83.8 (78.3, 89.3) | 14.3 (10.9, 18.5) | 43.7 (38.6, 49.2) | 62.2 (56.6, 67.6) |
| Observed mean infection (EPG)3 | 179 (171, 188) | 152 (141, 163) | 307 (289, 325) | 396 (326, 466) | 331 (301, 361) | 283 (260, 306) |
| Estimated mean infection (EPG)4 | 132 (101, 167) | 104 (84, 128) | 282 (249, 321) | 220 (150, 316) | 261 (208, 325) | 262 (221, 312) |
| Sensitivity5 | ||||||
| 1 sample (%) | 59.4 (47.6, 70.2) | 48.0 (40.8, 55.8) | 70.2 (66.1, 74.1) | 57.1 (44.5, 68.8) | 47.1 (41.7, 52.5) | 53.8 (50.1, 57.7) |
| 2 samples (%) | 72.9 (59.5, 84.6) | 62.3 (53.5, 71.3) | 83.5 (79.3, 87.3) | 81.0 (69.1, 90.1) | 71.8 (65.9, 77.3) | 78.5 (74.59, 81.9) |
| 3 samples (%) | - | 69.0 (59.8, 78.2) | 88.2 (84.2, 91.8) | - | 84.9 (80.0, 89.1) | 89.9 (87.3, 92.2) |
| 4 samples (%) | - | - | 90.7 (86.8, 94.0) | - | - | 95.2 (93.6, 96.6) |
| Day-to-day variation (r) | 1.10 (0.80, 1.46) | 0.83 (0.67, 1.02) | 0.87 (0.77, 0.99) | 0.25 (0.15, 0.37) | 0.15 (0.13, 0.19) | 0.20 (0.17, 0.23) |
| Aggregation (α) | 0.09 (0.05, 0.13) | 0.08 (0.05, 0.11) | 0.05 (0.04, 0.07) | 0.22 (0.04, 0.90) | 0.32 (0.06, 1.23) | 0.19 (0.05, 0.68) |
1 Parameter posterior mean estimates and 95% Bayesian credible interval
2 k is the number of samples taken in a study; N the number of participants with at least one sample
3 The observed mean infection is the mean egg count of all individuals tested positive in at least one Kato-Katz thick smear
4 The estimated mean infection is μf + μm
5 The sensitivity was calculated using eq 4