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. Author manuscript; available in PMC: 2018 Sep 19.
Published in final edited form as: Biochemistry. 2017 Sep 6;56(37):4972–4984. doi: 10.1021/acs.biochem.7b00573

Figure 1.

Figure 1

HCV genome and predicted secondary structures for the 3′X region and the 3′-end of the HCV gRNA. (A) The HCV genome contains 5′- and 3′-UTRs and a polyprotein-coding ORF. (B) The 3′X region is proposed to form a long-range interaction with the upstream CRE element via the complementary loop residues between 5BSL3.2 and SL2. (C) The SL2 kissing-loop residues (orange) are readily exposed in the proposed 3SL conformation of the 3′X region. (D) The extended SL2/3 stem–loop structure is shown in the 2SL conformation, which sequesters the SL2 kissing-loop residues.