Table 2.

Adjusted hazard ratios for the adjusted rate of disorder by age of menarche

	Age of menarche onset (HR; 95% CI)
	≤10		11		13		≥14
Distress disorders
Bipolar	3.9	1.1 – 14.2	4.4	1.2 – 16.8	1.9	0.5 – 7.0	0.6	0.1 – 3.5
Dysthymia	2.3	1.0 – 5.2	3.5	1.6 – 7.6	1.2	0.5 – 3.1	1.6	0.5 – 5.7
GAD	1.0	0.5 – 2.2	1.2	0.4 – 3.8	1.0	0.5 – 2.2	0.4	0.1 – 1.4
Major depression	1.8	1.2 – 2.7	1.7	1.0 – 2.6	0.7	0.4 – 1.1	0.3	0.2 – 0.6
PTSD	1.6	0.7 – 3.6	1.4	0.7 – 2.7	0.8	0.4 – 1.5	0.4	0.1 – 1.2
Fear disorders
Agoraphobia	2.2	0.9 – 5.5	0.7	0.2 – 2.2	0.4	0.1 – 1.5	0.3	0.1 – 1.5
Panic	1.1	0.5 – 2.4	0.7	0.4 – 1.6	0.5	0.2 – 1.3	0.1	0.01 – 0.3
Social phobia	2.7	1.4 – 5.3	1.0	0.5 – 1.7	0.6	0.3 – 1.2	0.2	0.1 – 0.7
Specific phobia	4.9	2.0 – 12	1.4	0.5 – 4.0	1.0	0.3 – 3.5	0.2	0.02 – 1.7
Eating disorders
Anorexia	0.2	0.01 – 2.5	--	-	1.7	0.3 – 10.2	1.2	0.2 – 6.0
Binge	1.0	0.6 – 1.5	0.9	0.5 – 1.4	1.2	0.8 – 1.9	0.6	0.3 – 1.2
Bulimia	1.0	0.3 – 3.1	0.2	0.1 – 1.1	0.5	0.2 – 1.0	0.3	0.1 – 1.1
Externalizing disorders
Alcohol	0.7	0.4 – 1.3	1.1	0.6 – 2.1	0.9	0.5 – 1.6	1.0	0.5 – 1.7
Conduct	0.5	0.2 – 1.5	0.6	0.2 – 1.6	0.7	0.3 – 1.6	0.6	0.1 – 2.4
Drug	1.0	0.6 – 1.8	0.9	0.6 – 1.5	1.0	0.6 – 1.6	1.2	0.9 – 1.7
Nicotine	1.7	1.1 – 2.7	1.9	1.2 – 2.9	1.4	0.9 – 2.1	1.2	0.7 – 2.1
ODD	0.6	0.3 – 1.3	0.9	0.5 – 1.8	0.6	0.3 – 1.4	0.3	0.1 – 1.2

^*Reference group for all hazard ratios is menarche onset at age 12 Models adjusted for BMI, parent income, age, race/ethnicity, number of parents in the household, exposure to or experience of childhood threat and deprivation.

GAD=general anxiety disorder, MDD=major depressive disorder, PTSD=Post-traumatic stress disorder, ODD=oppositional defiant disorder.