Table 2.

The Seven Prioritized Exome Variants in Family B

Chromosome	Position	Ref	Alt	Gene	ExAC	A	U	P	AJexOR	AJexP
15	45402883	G	C	DUOX2	0.011	0.37	0.15	1.6 × 10-4	1.2	.26
15	42281657	C	T	PLA2G4E	8.0 × 10-4	0.32	0.12	3.2 × 10-4	0.6	.032
5	44809369	C	T	MRPS30	0.011	0.29	0.15	8.2 × 10-3	1.1	.84
16	50763778	G	GC	NOD2	0.013	0.42	0.21	9.7 × 10-3	3.1	2.1 × 10-25
1	179660076	T	TGAGG	TDRD5	ND	0.29	0.15	.019	0.7	.25
3	48414274	C	T	FBXW12	0.014	0.32	0.14	.020	1.1	.50
1	117492067	T	G	PTGFRN	1.9 × 10-4	0.29	0.14	.030	1.3	.51

A, allele frequency in cases; AJexOR, replication odds ratio; AJexP, replication P value; Alt, alternative allele; ExAC, population allele frequency; P, LDAK P value; ND, no data available; Ref, reference allele; U, allele frequency in unaffected individuals.