Table 3.
Organ failures, laboratory parameters and outcome of acute-on-chronic liver failure patients with respect to acute-on-chronic liver failure grade n (%)
| ACLF0 (n = 6) | ACLF1 (n = 7) | ACLF2 (n = 24) | ACLF3 (n = 33)1 | P value | |
| Organ failures-clif-sofa score | |||||
| Liver | 1 (16.7) | 1 (14.3) | 12 (50) | 27 (81.8) | < 0.0001 |
| Kidney | 0 | 4 (57.1) | 10 (41.7) | 25 (75.8) | 0.002 |
| Cerebral | 0 | 1 (14.3) | 2 (8.3) | 13 (39.4) | 0.018 |
| Coagulation | 1 (16.7) | 1 (14.3) | 16 (66.7) | 25 (75.8) | 0.002 |
| Circulation | 0 | 0 | 7 (30.4) | 26 (78.8) | < 0.0001 |
| Respiration | 0 | 0 | 2 (8.3) | 7 (21.2) | 0.22 |
| Chronic renal disease | 0 | 2 (28.6) | 5 (20.8) | 3 (9.1) | 0.245 |
| Laboratory data (mean) | |||||
| Leucocyte count at baseline, × 109/L | 8 (6-11) | 11 (6-16) | 10 (7-12) | 12 (10-13) | 0.256 |
| Platelet count at baseline | 127 (42-212) | 61 (40-82) | 104 (78-129) | 149 (105-193) | 0.105 |
| Bilirubin at baseline, mg/dL | 7.0 (4.2-9.8) | 7.7 (-3.1-18.5) | 10 (4.9-15.1) | 13.9 (9.9-17.8) | 0.29 |
| Peak bilirubin, mg/dL | 11.3 (4.1-18.5) | 10.7 (-4.2-25.5) | 14.1 (9.1-19) | 23 (18.7-27.3) | 0.009 |
| Creatinine at baseline, mg/dL | 0.9 (0.4-1.3) | 2.1 (1.3-2.9) | 1.4 (1.1-1.8) | 1.8 (1.1-2.4) | 0.232 |
| Peak creatinine, mg/dL | 0.9 (0.5-1.2) | 2.2 (1.4-3.1) | 1.8 (1.4-2.1) | 3.1 (2.6-3.7) | < 0.0001 |
| Lactate at baseline, mmol/L | 2.1 (1.4-2.7) | 2.3 (2.1-2.6) | 2.4 (1.7-3.2) | 4.1 (2.4-5.7) | 0.225 |
| MELD score at baseline (mean) | 23 (20-26) | 21 (11-31) | 20 (17-24) | 26 (23-30) | 0.113 |
| Liver transplantation | 1 (16.7) | 0 | 6 (26.1) | 1 (3) | 0.043 |
| Mortality during admission | 0 | 3 (42.9) | 10 (41.7) | 28 (84.8) | < 0.0001 |
| 90-d mortality | 0 | 3 (42.9) | 11 (45.8) | 29 (87.9) | < 0.0001 |
1
Only patients with cirrhosis were included in this analysis. P-value of comparison of patients with ACLF grade 0, 1, 2 and 3. ACLF: Acute-on-chronic liver failure.