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. 2017 Oct 16;7:13267. doi: 10.1038/s41598-017-13122-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Corneal wound healing is delayed in BLT2 KO mice. (A) Representative macroscopic images of fluorescein-stained corneal wounds in BLT2 WT and BLT2 KO mice at the indicated times after wounding. (B) Corneal wound area was measured in 11–12 weeks old BLT2 WT and BLT2 KO mice. Data were analyzed by two-way ANOVA: ***p < 0.001. (n = 8–12) (C) Corneal wounds were measured in BLT2 KO mice after treatment with 0.1% diclofenac for 2 days. Data were analyzed by two-way ANOVA; n.s.: not significant. (D) Corneal wounds were measured in 10 week old WT mice after treatment with 0.1% diclofenac for 2 days and treatment of 100 nM 12-HHT or 10 µM CAY10583 (BLT2 agonist). Data were analyzed by two-way ANOVA (8–32 hour); *p < 0.05 **p < 0.01 (n = 5–6).