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. 2017 Oct 16;7:13267. doi: 10.1038/s41598-017-13122-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of how the 12-HHT/BLT2 signaling pathway functions in corneal wound healing, and how NSAIDs delay healing. (A) 12-HHT activates BLT2 signaling and subsequently accelerates corneal epithelial cell migration, resulting in healing of corneal wounds. (B) NSAID eye drops inhibit production of 12-HHT in the eye, resulting in suppression of downstream events and ultimately delaying the corneal wound healing process.