Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 16;7:13234. doi: 10.1038/s41598-017-13364-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

HCG18 is up-regulated in IDD patients. (A) Alignment of miR-146a-5p sequence with HCG18 and with HCG18 mutated at the putative binding site (37–43 region of HCG18, AGTTCTC). (B) The correlation between HCG18 level and miR-146a-5p expression was measured in NP tissues from the patients with bulging and herniated discs (n = 60). Spearman’s correlation coefficient r = 0.4796, P = 0.0006. (C) Luciferase reporter activity in NP cell was detected after co-transfection miR-con/miR-146a-5p mimics (25 nM) and luciferase vector (pmiR-GLo) containing the wild type/mutant HCG18 (100 ng/L). (D) HCG18 expression was measured by qPCR from control, bulging and herniated NP tissues (n = 90). (E) The relative expression of HCG18 in NP tissue from IDD patients and controls (n = 90). (F) The correlation between the expression of HCG18 and patients’ pfirrmann score (n = 60). Spearman’s correlation coefficient r = 0.7245, P = 0.0001. *P < 0.05.