Fig. 7.

A schematic diagram of model displaying the implication of MIIP in PKCε activation-induced tumor metastasis. PKCε phosphorylates MIIP at Ser303 and promotes its interaction with RelA, which protects RelA from deacetylation by HDAC6; in turn, this leads to enhancement of RelA transcriptional activity and increase of genes expression relevant to cell invasion. PP1 acts as a phosphotase being able to dephosphorylate MIIP phosphorylation by PKCε. In cancer cells, PKCε activity is hyperactive while PP1 protein levels is downregulated; thereby, PKCε /MIIP/RelA signaling is reinforced and faciliates tumor metastasis