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. 2017 Oct 16;7:13302. doi: 10.1038/s41598-017-13440-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional networks of MCM2-regulated phosphoproteins. (a) Functional enrichment analysis of proteins with differential expression under MCM2 silencing (red) and proteins with differential change in phosphorylation levels under MCM2 overexpression (blue) or silencing (yellow). According to corrected p-value < 0.05, 76 over-represented GO terms were identified. (b) Ten protein complexes that are over-represented in response to MCM were obtained from CORUM. Variable protein members of the complex are colored depending on the phosphoproteomic or global proteomic profiles.