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. 2017 Oct 16;7:13244. doi: 10.1038/s41598-017-13802-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combining gal-8 and gal-9 increases the predictive value for OS and HFS. (A) Kaplan-Meier curves of the 5-years OS and 5-years DFS according to the presence of either or both gal-8 and gal-9 in the plasma of HGSC patients. Blue bar: Gal-8^LOW/Gal-9^LOW, green bar: Gal-8^High/Gal-9^LOW, Yellow bar: Gal-8^LOW/Gal-9^High, Magenta bar: Gal-8^High/Gal-9^HIGH. (B) Correlation between the concentration of gal-8 and gal-9 in the plasma of HGSC patients. (C) Kaplan-Meier curves of the 5-years OS and 5-years DFS according to the presence of both gal-8 and gal-9 in the plasma of HGSC patients. Blue bar: Gal-8^LOW/Gal-9^LOW, Gal-8^High/Gal-9^LOW or Gal-8^LOW/Gal-9^High sample; Red bar: Gal-8^High/Gal-9^HIGH samples. Patients with plasma gal-8 ≥ 2.7 ng/ml or plasma gal-9 ≥ 0.73 ng/ml were considered Gal-8^High and Gal-9^High, respectively.