Table 1.
Significant effects of prenatal VPA exposure and sex on the activity of independent components in rats.
| IC | Activity | P | |
|---|---|---|---|
| Decreased by VPA treatment | VPA-treated | Control | |
| Olfactory bulb (IC37) | −0.12 ± 0.02 | −0.04 ± 0.02 | <0.001 |
| Thalamus (IC3) | 0.07 ± 0.01 | 0.11 ± 0.01 | 0.002 |
| Increased by VPA treatment | VPA-treated | Control | |
| Caudoputamen, left (IC29) | 0.07 ± 0.01 | 0.01 ± 0.01 | <0.001 |
| Decreased in males | Male | Female | |
| Visual cortex (IC5) | −0.15 ± 0.02 | −0.05 ± 0.01 | <0.001 |
| Medulla (IC2) | −0.16 ± 0.01 | −0.08 ± 0.02 | <0.001 |
| Inferior colliculus (IC4) | −0.06 ± 0.01 | 0.00 ± 0.01 | <0.001 |
| Cerebellum (IC8) | −0.29 ± 0.02 | −0.21 ± 0.01 | 0.002 |
| Superior colliculus and inferior colliculus, left and retrosplenial cortex (IC11) | −0.05 ± 0.01 | 0.00 ± 0.01 | 0.005 |
| Somatosensory cortex (IC13) | 0.05 ± 0.02 | 0.13 ± 0.01 | 0.004 |
| Increased in males | Male | Female | |
| Motor cortex, left and orbitofrontal cortex, left (IC4) | 0.06 ± 0.01 | 0.00 ± 0.01 | <0.001 |
| Somatosensory cortex (IC8) | 0.29 ± 0.02 | 0.21 ± 0.01 | 0.002 |
A FDR ≤ 0.05 was considered as statistically significant. VPA, valproic acid; IC. Independent component.