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Ex vivo autoradiograms of pancreas in vivo distribution of [177Lu]Lu-DO3A-VS-Cys40-Exendin4 in rat (a), mouse (b), pig (c), and non-human primate (d). The islet contrast (e) defined as the islets-to-exocrine pancreas (IPR) ratio was highly dependent on the species, mainly reflecting the difference in background binding. Error bars represent standard deviations. **denote p < 0.01, ***denote p < 0.001 and ****denote p < 0.0001
