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. 2017 Sep 11;54(11):1039–1045. doi: 10.1007/s00592-017-1046-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Theoretical binding pattern of [⁶⁸Ga]Ga-DO3A-VS-Cys⁴⁰-Exendin4 in pancreas in vivo, based on the species dependent islet contrast observed by ex vivo autoradiography. Each entire bar represents 100% of the uptake in pancreas in respective species, and each colored field is proportional in area to its predicted contribution to the total in vivo PET signal. The contribution of GLP-1R mediated binding in islets is indicated in blue. The predicted GLP-1R mediated binding in exocrine pancreas is indicated in bright red. Off-target binding, i.e., non-specific binding not mediated by GLP-1R throughout the pancreas, is indicated in yellow (color figure online)