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. 2017 Oct 16;7:13262. doi: 10.1038/s41598-017-13650-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutational difference of primary/metastatic tissues. The differentially mutated genes in cancer types (A). The left panel indicates the mutational rate in metastatic and primary cancerous tissues; the top panel refers to the mutational frequencies of each sample in regions detected; the green barplot in the right panel represents the log2 transformed p values of mutational difference between metastatic and primary tissues; the blue barplot in the right panel indicates the mutational odds ratio of metastatic/primary mutation rates; the middle panel refers to the mutation type of each sample in each gene. The mutational difference between primary and metastatic tissue on each amino acid was shown in needle plot (B). The height represents the mutational counts in different regions and domains, the needles upward indicates the primary and needles on the other side refers to metastatic tissues. The mutational difference between primary/metastatic tissue was also shown (C). Mutational exclusive pairs in primary/metastatic tissues in each cancer type (D). The width of each bar indicates the pair number and the height indicates the proportion.