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. 2017 Oct 16;7:12756. doi: 10.1038/s41598-017-12934-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SRVF dramatically alters cell morphology and decreases cell viability in malignant cancer cells. (A) HT1080 cells were incubated with the indicated doses of SR, VF, or SRVF at concentrations of 50, 100, or 250 µg/ml for 24 h and photographed at a magnification of ×200 under an inverted microscope. (B) Cell viability after incubation with SR, VF, or SRVF was determined using the CCK assay and is expressed as the mean ± standard deviation (SD). (C) Cells were seeded onto the E-Plate 16, treated with SR, VF, or SRVF at a concentration of 250 µg/ml, and cell proliferation was monitored using the xCELLigence system. Data are representative of two independent experiments performed in triplicate and are expressed as the mean ± SD. (D,E) The effects of SR, VF, or SRVF on cell viability of MDA-MB231 (D) and HepG2 (E) cells were evaluated by the CCK assay and are expressed as the mean ± SD. Statistical significance was determined with Student’s t-test. *p < 0.05, **p < 0.05 vs. untreated control.