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. 2017 Oct 16;8:959. doi: 10.1038/s41467-017-00931-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — NCoR1 deficiency leads to a blockade in positive selection. a The surface expression of CD69 and TCRβ detected by flow cytometry on NCoR1-deficient (cKO) and wild-type (WT) thymocytes (n = 5 for each group). b Quantification of each subpopulation gated in (a). c, e The expression profiles of CD4 and CD8 (left) on total thymocytes from cKO and WT OT-II TCR-transgenic mice in the Rag1 ^+/+ (c, n = 4) or Rag1 ^−/− (e, n = 3) background. The right panel shows the percentages of CD4⁺ single-positive (SP) thymocytes gated in the left panel. d, f The expression of TCR Vα2 detected by flow cytometry on total thymocytes from cKO and WT OT-II TCR-transgenic mice in Rag1 ^+/+ (d, n = 4) or Rag1 ^−/− (f, n = 3) background. The right panel shows the quantification of TCR Vα2⁺ thymocytes gated in the left panel. The data are representative of three independent experiments (a–f). Statistical significance was analyzed using the two-tailed Student’s t test (*P < 0.05; **P < 0.01; ***P < 0.001)