Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 12;8:1306. doi: 10.3389/fimmu.2017.01306

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 He, Gong, Chen, Zhou, Gong and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of soluble calreticulin (sCRT) activity on tumorigenesis. When sCRT or its fragment was released from tumors under pressure, sCRT showed a protumorigenesis activity, because of accumulation of Gr1⁺ myeloid derived suppressor cells (G-MDSCs) in vivo. The possible molecular mechanisms include: (a) sCRT could recruit MDSCs in tumor sites from blood; (b) IMC in bone marrow expanding when stimulated by sCRT; (c) the apoptosis of MDSCs could also be inhibited by sCRT; and (d) differentiation of MDSCs toward DC could be inhibited by sCRT.