Figure 5.

Impact of galectin-1-deficiency on control of Leishmania donovani. Parasite burdens in C57BL/6 [wild-type (WT); open circles] and Lgals1^−/− (closed triangles) mice (n = 4–5 per time point) infected with L. donovani were measured in the liver (A) and spleen (B), as indicated, on days 7, 14, 28, and 56 p.i. The frequencies and total numbers of IFNγ-producing CD4⁺ T cells, Tr1 cells, and IL-10-producing Treg cells in the liver (C) and spleen (D) at day 14 p.i. were measured, as indicated. These data represent one of three separate experiments (*p < 0.05, **p < 0.01; Mann–Whitney test, Lgals1^−/− relative to WT at time-point assessed).