Skip to main content
. 2017 Oct 16;7:13190. doi: 10.1038/s41598-017-13196-4

Table 1.

Associations between Vascular Features (VFs) and genes in the 14GT signature. The 9 VFs and correlated genes are divided based on their higher average expression in good versus poor outcomes groups. While VFs associated with poor prognosis demonstrate high intratumoral variance (standard deviation), those associated with good prognosis indicate a relationship between high vascularity and hot/cold spots of vascular density and favorable prognosis.

Standard Deviation of Features Correlated genes
Associated with Poor Outcome Arm orientations* ADH5, NLRC4, RPL36A, RPLP2, SLC16A4, TNFSF8, ZNF16, SGCB, GOSR2
BP Lacunarity*
EC Lacunarity
EC Density*
Skewness (S) and Kurtosis (K) of feature distribution Correlated genes
Associated with Good Outcome Arm number (S*, K) IFNA13, CMYA5, STAT3, KCNJ12, MED10
EC Density (S, K*)
Arm Lacunarity (K*)

Asterisks (*) indicate VFs that correlate with genes in the 14GT signature.