Table 1.

Associations between Vascular Features (VFs) and genes in the 14GT signature. The 9 VFs and correlated genes are divided based on their higher average expression in good versus poor outcomes groups. While VFs associated with poor prognosis demonstrate high intratumoral variance (standard deviation), those associated with good prognosis indicate a relationship between high vascularity and hot/cold spots of vascular density and favorable prognosis.

	Standard Deviation of Features	Correlated genes
Associated with Poor Outcome	Arm orientations*	ADH5, NLRC4, RPL36A, RPLP2, SLC16A4, TNFSF8, ZNF16, SGCB, GOSR2
	BP Lacunarity*
	EC Lacunarity
	EC Density*
	Skewness (S) and Kurtosis (K) of feature distribution	Correlated genes
Associated with Good Outcome	Arm number (S*, K)	IFNA13, CMYA5, STAT3, KCNJ12, MED10
	EC Density (S, K*)
	Arm Lacunarity (K*)

Asterisks (*) indicate VFs that correlate with genes in the 14GT signature.