Table 2.

Functional annotation of genes in 14 genes correlated to 9VFs and recapitulating the risk prediction of the 9VFs. Annotation of genes was performed manually through PubMed. Associated citations may be found as part of Supplementary Table S5.

	Gene name	Activity	Disease association
CMYA5**	Cardiomyopathy-associated 5	Desmin binding, Vesicular transport	Cardiomyopathy, schizophrenia
STAT3**	Signal transducer and activator of transcription 3	Signal transduction, Gene transcription	Angiogenesis, Vascular leakage
ADH5**	alcohol dehydrogenase 5	Opposes NO signaling, protein denitrosylation	Impaired cardiovascular function
NLRC4	NLR family CARD domain containing 4	Innate immunity inflammosome	Inflammatory disease, infantile enterocolitis
RPL36A***	Ribosomal protein L36	60S ribosomal subunit Translational regulation	Hepatocellular carcinoma
RPLP2***	ribosomal protein lateral stalk subunit P2	Phosphoprotein involved in protein elongation	Upregulated in many cancers
SLC16A4*	Solute carrier family 16 member 4	Monocarboxylate transporter for pH and energy homeostasis	Prognostic biomarker in ccRCC
TNFSF8	tumor necrosis factor superfamily member 8	CD30 ligand	Inflammation
ZNF16	zinc finger protein 16	Transcription factor	Erythroid and megakaryocyte differentiation
IFNA13**	interferon alpha 13	Inflammatory/reproductive cytokine	Downregulated in dilated cardiomyopathy
SGCB**	Sarcoglycan beta	Dystrophin complex, sarcoglycan transport	Limb-girdle muscular dystrophy cardiomyopathy
KCNJ12**	potassium voltage-gated channel subfamily J member 12	Repolarization of cardiac muscle	Dilated cardiomyopathy
MED10**	mediator complex subunit 10	RNA Pol-II transcriptional regulation	Heart valve development
GOSR2**	golgi SNAP receptor complex member 2	Vesicular trafficking	Familial essential hypertension
*Prognostic renal cancer biomarker		**Association with vascular or heart biology	***Cancer association