Table 3.
Distribution of genotypes frequency in three positions of CTLA-4 gene polymorphisms.
| CTLA-4 locus +49 A/G | Control (n=65) N (%) | Patients (n=65) N (%) | P value Crude | OR Crude (95% C.I.) | P value adjusted* | OR adjusted* (95% C.I.) |
|---|---|---|---|---|---|---|
| AA | 39 (60) | 51 (78.46) | Ref | |||
| AG | 17 (26.15) | 0 (0) | 0. 99 | - | - | - |
| GG | 9 (13.84) | 14 (21.53) | 0.84 | 0.90 | 0.84 | 0.90 |
| (0.35-2.33 ) | (0.35-2.33 ) | |||||
| AA | 39 (60) | 51 (78.46) | 0.1 | 2.76 | ||
| AG/GG | 26 (39.99 | 14 (21.53) | 0.024 | 2.43 | (0.81-9.40) | |
| (1.12-5.26) | ||||||
| Allele Frequency | ||||||
| A | 95 (73.07) | 102 (78.46) | 0.31 | 1.34 | 0.31 | 1.34 |
| G | 35 (26.92) | 28 (21.53) | (0.76-2.37) | (0.76-2.37) | ||
| CTLA-4 locus -318 T/C | Control (n = 65) N (%) | Patients (n = 65 ) N (%) | P value Crude | OR Crude (95% C.I.) | P value adjusted* | OR adjusted* (95% C.I.) |
| CC | 55 (48.61) | 55 (48.61) | Ref | |||
| CT | 9 (13.84) | 10 (15.38) | 0.83 | 0.90 | 0.83 | 0.90 |
| (0.34-2.39) | (0.34-2.39) | |||||
| TT | 1 (1.53) | 0 (0) | 1 | - | - | - |
| CC | 55 (84.61) | 55 (84.61) | 1 | 1 | 1 | 1 |
| CT/TT | 10 (15.37) | 10 915.37) | (0.39-2.59) | (0.39-2.59) | ||
| Allele Frequency | ||||||
| C | 119 (91.53) | 120 (92.30) | 0.82 | 1.11 | 0.31 | 1.34 |
| T | 11 (8.46) | 10 (7.69) | (0.45-2.71) | (0.76-2.34) | ||
| CTLA-4 locus -1661 A/G | Control (n = 65) N (%) | Patients (n = 65 ) N (%) | P value Crude | OR Crude (95% C.I.) | P value adjusted* | OR adjusted* (95% C.I.) |
| AA | 23 (35.38) | 5 (7.46) | Ref | |||
| AG | 38 (58.46) | 57 (85.07) | 0.00031 | 0.14 | 0.00031 | 0.14 |
| (0.05-0.41) | (0.05-0.41) | |||||
| GG | 4 (6.15) | 5 (7.46) | 0.04 | 0.17 | 0.04 | 0.17 |
| (0.03-0.89) | (0.03-0.89) | |||||
| AA | 23 (35.38) | 5 (7.46) | 0.0003 | 0.15 | 0.0003 | 0.15 |
| AG/GG | 42 (64.61) | 62 (92.53) | (0.05-0.42) | (0.05-0.42) | ||
| Allele Frequency | ||||||
| A | 84 (66.61) | 67 (0.5) | 0.096 | 0.67 | 0.096 | 0.67 |
| (0.14-1.08) | (0.14-1.08) | |||||
| G | 56 (35.38) | 67 (0.5) | ||||
| CTLA-4 locus -1772 T/C | Control (n = 65) N (%) | Patients (n = 65 ) N (%) | P value Crude | OR Crude (95% C.I.) | P value adjusted* | OR adjusted* (95% C.I.) |
| TT | 64 (95.52) | 56 (86.15) | Ref | |||
| CT | 2 (2.98) | 8 (12.30) | 0.06 | 0.22 | 0.06 | 0.22 |
| (0.04-1.07) | (0.04-1.07) | |||||
| CC | 1 (1.49) | 1 (1.53) | 0.92 | 0.87 | 0.92 | 0.87 |
| (0.05-14.31) | (0.05-14.31) | |||||
| CC | 1 (1.49) | 1 (1.53) | 0.07 | 0.29 | 0.07 | 0.29 |
| CT/TT | 66 (98.5) | 64 (98.45) | (0.08-1.13) | (0.08-1.13) | ||
| Allele Frequency | ||||||
| C | 130 (97.01) | 120 (92.30) | 0.099 | 0.37 (0.11-1.21) | 0.099 | 0.37 (0.11-1.21) |
| T | 4 (2.98) | 10 (7.69) | ||||
*
Adjusted based on transfusion, tattoo and addiction
C.I. = Confidence interval