Table 1.

Metabolites, their molecular formula, function, fragmentation results detected in the exometabolome of D. shibae and P. inhibens, in other studies, a mesocosm (Osterholz et al., 2015) and in a North Sea phytoplankton bloom (Noriega-Ortega et al., in preparation).

Metabolites	Molecular formula	Function	Fragmentation	D. shibae	P. inhibens	Other studies	Mesocosm	North Sea bloom
HET (4-methyl-5-(β-hydroxyethyl)thiazole)	C6H9NOS	vitamin B1 precursor		+	+
Thiamine phosphate	C10H15N2O8P	vitamin B1		+	+	G, J
Dimethyl-D-ribityl-lumazine	C13H18N4O6	vitamin B2 precursor	+	+	+	R
Riboflavin	C17H20N4O6	vitamin B2	+	+	+	F, R, G, J
Pantoate	C6H12O4	vitamin B5 precursor		+
Pantothenate	C9H17NO5	vitamin B5		+	+	G, J
Pyridoxal	C8H9NO3	vitamin B6 related		+	+		+	+
Pyridoxal phosphate	C8H10NO6P	vitamin B6		+	+
Dethiobiotin	C10H17N2O3	vitamin B7 precursor			+
Alpha-ribazole	C14H18N2O4	vitamin B12 precursor	+	+	+	R, J	+	+
Alpha-ribazole-5-phosphate	C14H19N2O7P	vitamin B12 precursor		+	+			+
Pyrroloquinoline quinone	C14H6N2O8	vit. B - cofactor	+	+
6-(2-amino-2-carboxylatoethyl)−1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate	C14H14N2O6	vit. B - cofactor		+			+	+
Methyl (indole-3-yl)acetate	C11H11NO2	IAA related		+	+		+
Tryptophan	C11H12N2O2	IAA precursor		+	+	F, R, G	+
Indole_acetate	C10H9NO2	IAA		+		F
2,3-dihydroxybenzoate	C7H5O4	siderophore building block		+		F
3-4-dihydroxybenzoate	C7H6O4	siderophore building block			+
PAI-1 (N-(3-oxododecanoyl)-L-homoserine lactone)	C16H27NO4	quorum-sensing	+	+	+
AAI	C12H19NO4	quorum-sensing		+	+		+
VAI-2	C12H21NO3	quorum-sensing		+	+
VAI-1	C10H15NO4	quorum-sensing		+	+		+	+
HAI-1	C8H13NO4	quorum-sensing		+	+		+
N-3-hydroxydecanoyl-L-homoserine lactone	C14H25NO4	quorum-sensing	+		+	J
Porphobilinogen	C10H14N2O4	AA derivate		+	+		+	+
Tyrosine	C9H11NO3	AA		+	+	R, G	+	+
Arogenate	C10H13NO5	AA precursor		+	+	R	+	+
4-Hydroxy-phenylpyruvate	C9H8O4	AA precursor		+	+		+	+
Phenylalanine	C9H11NO2	AA		+		F, R, G	+	+
L-SDAP	C11H18N2O7	AA precursor		+	+
2-Isopropylmaleate	C7H10O4	AA precursor		+	+	R	+
Delta-piperideine-2-6-dicarboxylate	C7H9NO4	AA precursor		+	+		+	+
O-Acetyl-L-homoserine	C6H11NO4	AA derivate		+	+		+
Histidine	C6H9N3O2	AA		+	+	G, J
Miraxanthin V	C17H18N2O6	betaxanthine			+		+	+
L-Dihydroxy-phenylalanine	C9H11NO4	betaxanthine			+		+	+
Glutathione	C10H17N3O6S	defense		+	+	R
Tropodithietic acid	C8H4O3S2	antibiotic	+		+
Inosine	C10H12N4O5	purin metabolism		+	+	F, R
Thymidine	C10H14N2O5			+		R	+	+
Deoxycytidine	C9H13N3O4			+	+
Phenylacetylcarbinol	C9H10O2				+			+
S-Methyl phenylethanethioate	C9H10OS				+	T

F, Fiore et al. (2015); G, Garcia et al. (2015); J, Johnson et al. (2016); R, Romano et al. (2014); T, Thiel et al. (2010). Garcia et al. inferred the metabolites in cocultures on the basis of genomic information. +, Detected; AA, amino acid; IAA, indole acetic acid.