Table 3.

Predictive values (with 95% confidence intervals) of punctate lesions to estimate motor outcome with different numerical cut-offs for lesion load.

Outcome measure	>3 PWML on MRI		>6 PWML on MRI		>20 PWML on MRI
	GMFCS 2–5	Motor score <85	GMFCS 2–5	Motor score <85	GMFCS 2–5	Motor score <85
Sensitivity	0.57 (0.32–0.78)	0.29 (0.18–0.43)	0.57 (0.33–0.79)	0.24 (0.13–0.39)	0.57 (0.33–0.79)	0.22 (0.13–0.36)
Specificity	0.85 (0.81–0.89)	0.85 (0.81–0.89)	0.9 (0.87–0.93)	0.9 (0.86–0.93)	0.94 (0.91–0.96)	0.94 (0.91–0.96)
Positive predictive value	0.13 (0.06–0.23)	0.2 (0.11–0.32)	0.17 (0.08–31.4)	0.24 (0.13–0.39)	0.27 (0.12–0.46)	0.33 (0.17–0.53)
Negative predictive value	0.98 (0.96–0.99)	0.9 (0.87–0.93)	0.98 (0.96–0.99)	0.9 (0.87–0.93)	0.98 (0.97–0.99)	0.9 (0.87–0.93)
Positive likelihood ratio	3.89 (2.32–6.5)	1.98 (1.17–3.35)	5.73 (3.32–9.88)	2.44 (1.34–4.46)	9.9 (5.36–18.19)	3.89 (1.95–7.78)
Negative likelihood ratio	0.5 (0.27–0.92)	0.83 (0.69–1)	0.48 (0.26–0.87)	0.84 (0.71–0.99)	0.46 (0.25–0.83)	0.82 (0.7–0.97)
Diagnostic odds ratio	7.74 (2.59–23.15)	2.38 (1.17–4.84)	12.03 (3.97–36.53)	2.91 (1.36–6.25)	21.76 (6.94–68.21)	4.71 (2.1–10.87)

GMFCS, Gross Motor Function Classification System; PWML, punctate white matter lesions.