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. 2017 Oct 10;21(2):341–350. doi: 10.1016/j.celrep.2017.09.061

Figure 3.

Figure 3

Homeostatic Changes in Neurotransmitter Release Are Driven by P/Q-type VGCC

(A and B) Sample images showing response of SypH 2x-expressing terminals treated as indicated to a low-frequency 100 AP train in the presence of folimycin and either ω-agatoxin IVA (A) or ω-conotoxin GVIA (B).

(C) Mean normalized responses in ω-agatoxin IVA: gabazine treatment, 0.975 ± 0.037 (n = 333 synapses from 15 cells); vehicle-treated control, 1 ± 0.031 (n = 416 synapses from 19 cells); TTX treatment, 0.912 ± 0.041 (n = 354 synapses from 17 cells).

(D) Mean normalized responses in ω-conotoxin GVIA: gabazine treatment: 0.876 ± 0.045 (n = 377 synapses from 11 cells); vehicle-treated control, 1 ± 0.039 (n = 375 synapses from 14 cells); TTX treatment, 1.264 ± 0.057 (n = 282 synapses from 12 cells). Shading or error bars represent ± SEM. ∗p < 0.05, ∗∗∗p < 0.001; ns, non-significant.