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. 2017 Oct 16;7:12892. doi: 10.1038/s41598-017-12940-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Composite IDO-1 score at diagnosis identifies patients at the highest risk of induction failure and early death. (A) IDO-1 mRNA expression by RT-PCR, normalized to 18S ribosomal RNA. The highest IDO-1 expression was found in the shortest survival group. Increased IDO-1 mRNA correlates with a shorter OS (*p = 0.01). (B) Composite IDO-1 score for each of the 4 survival groups, with highest IDO-1 expression correlating with a shorter OS. (C) Kaplan-Meir survival analysis of patients arbitrarily divided into two cohorts based on their composite IDO-1 score: “low” (<0.45) and “high” (≥0.45) (*p = 0.0005). (D) Kaplan-Meir survival analysis of composite IDO-1 score among the three risk groups as per the ELN classification system (*p = 0.005). (E) Figure showing patients who failed induction had higher composite IDO-1 scores (*p = 0.01).