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. 2017 Oct 16;7:12892. doi: 10.1038/s41598-017-12940-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TCGA database of AML patients downloaded from the UCSC website. (A) RNA seq and Illumina 450 K methylation array data was obtained and the FKPM value was used to divide the external cohort into two groups for survival analysis. Higher FKPM >0 correlates with a poor OS (*p = 0.0072). (B) For methylation array data, one of the three CpG sites assigned to IDO-1 (*cg10262052) was used to divide the cohort into two groups based on the median β-value. Higher median β-values of IDO-1 promoter methylation correlated with better outcomes (*p = 6e-04).