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. 2017 Oct 16;7:13297. doi: 10.1038/s41598-017-13567-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression of BMSC cultured in conditioned medium supplemented with protease inhibitors. miR-29b (white bars), COL1A1 (light grey bars) and COL3A1 (dark grey bars) gene expression of BMSC kept in micromass pellets and cultured for 7 days in chondrogenic medium conditioned with OA cartilage (CM) and supplemented with protease inhibitor cocktail including EDTA which additionally inhibits matrix metalloproteases (a) or without EDTA (b) compared to non-conditioned chondrogenic medium (NM, zero line, n = 7). Results are expressed as box plots with median, the 25^th and 75^th percentiles and whiskers showing the largest and smallest values. * = p < 0.05; non-parametric Wilcoxon signed rank test for paired analysis. CM: with OA cartilage conditioned medium; NM: non-conditioned medium.