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. 2017 Oct 16;7:12860. doi: 10.1038/s41598-017-13034-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of resveratrol administration on zebrafish infected by NTHi. Zebrafish were infected intraperitoneally with ∼5×10⁷ bacteria/individual. When necessary, resveratrol 0.1 mg/g/dose (RESV_0.1) was administered intraperitoneally at 29 and 53 hpi. (a) Effect of resveratrol administration on adult zebrafish survival upon NTHi375 infection. Non-infected groups were administered perfusion solution-DMSO (1:1) (triangle) or saline solution 0.9% (diamond); infected groups were administered perfusion solution-DMSO (1:1) (circle) or resveratrol (square). Survival rate is reported as percentage (mean ± SD) of adult individuals survival at 120 hpi. Survival of NTHi infected zebrafish was significantly higher in resveratrol treated- and in untreated animals (p < 0.0001). (b) Bacterial counts on zebrafish blood samples from the caudal fin were determined at 24 and 48 hpi (log₁₀ c.f.u./ml blood), corresponding to 5 h before- and 19 h post-resveratrol treatment, respectively. At 48 hpi, NTHi375 counts were lower in resveratrol treated (square) than in control vehicle administered (circle) zebrafish (p < 0.0001). Perfusion solution-DMSO (1:1) was used as vehicle solution.