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. 2017 Oct 16;7:13249. doi: 10.1038/s41598-017-13320-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of MDNPs. (A) TEM image of MDNPs showing smooth spherical morphology (250–280 nm). (B) Schematic representation of the stimuli-sensitive behavior of MDNPs and the structure of the PNIPAAm-CMC semi-IPN shell. (C) Controlled bi-phasic release of NU7441 was observed from the PLGA core at 37 °C. (D) Gemcitabine hydrochloride in the PNIPAAm-CMC shell showed pH-dependent release with the highest release at pH 6 and 37 °C (n = 4).