Table 1. Cut-off values of sperm DNA fragmentation tests for pregnancy rate prediction in neat semen samples during IVF/ICSI cycles.
| Study | SDF assay | Cut-off SDF index (%) |
|---|---|---|
| Larson-Cook 2003 (12) | SCSA | <27 |
| Gandini 2004 (13) | SCSA | <27 |
| Payne 2005 (14) | SCSA | <27 |
| Bungum 2007 (15) | SCSA | <30 |
| Speyer 2010 (16) | SCSA | <19, <30* |
| Simon 2014 (17) | SCSA | <27 |
| Oleszczuk 2016 (18) | SCSA | <20 |
| Henkel 2004 (19) | TUNEL | <36.5 |
| Frydman 2008 (20) | TUNEL | <35 |
| Esbert 2011 (21) | TUNEL | <36 |
| Yilmaz 2010 (22) | SCD | <30 |
| Anifandis 2015 (23) | SCD | <35 |
*, <19% for ICSI and <30% for IVF cycles. IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; SDF, sperm DNA fragmentation; SCSA, sperm chromatin structure assay; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; SCD, sperm chromatin dispersion.