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(A) Cardiomyocyte CSA was increased in WTO, GKS, and GKO rats. (B) Cardiac fibrosis was increased in GKS and GKO rats. *P<0.05 vs WTS, †P<0.05 vs WTO, ‡P<0.05 vs GKS; CSA, cardiomyocyte cross-sectional area; GKO, Goto–Kakizaki rats with ovariectomy; GKS, Goto–Kakizaki with sham operation; WTO, wild-type rats with ovariectomy; WTS, wild-type with sham operation.
