. 2016 Nov 9;2(2):67–80. doi: 10.1016/j.cdtm.2016.09.001

Table 1.

Comparisons of Tregs in chronic HBV infection, HC and other HBV-related liver diseases.

Markers	Positions	Comparisons of Treg frequencies	References
CD4⁺CD45RA⁻Foxp3^low	PBT and IHT	ACLF > AsC and CHB	46
CD4⁺CD25⁺Foxp3⁺	PBT	ACLF > CHB	47
CD4⁺CD25⁺	PBT	ACLF = AHB	48
CD4⁺CD25⁺	PBT	ACLF > CHB and HC	48
CD4⁺CD25⁺Foxp3⁺	PBT	ACLF > CHB and HC	49, 50
CD4⁺CD25⁺	PBT	ACLF > CHB and HC	28, 51
CD4⁺CD25⁺	TIT	ACLF > CHB and HC	28, 51
CD4⁺CD45RA⁻Foxp3^high	PBT and IHT	CHB > HC	46
CD4⁺CD45RA⁻Foxp3^high	PBT and IHT	ACLF > AsC	46
CD4⁺CD25^high	PBT	ACLF > CHB and HC	52
CD4⁺CD25⁺Foxp3⁺	PBT	CHB > HC	53, 54
CD4⁺Foxp3⁺	PBT and IHT	CHB > HC	55
CD25⁺CD127^low/−	PBT	CHB > AsC, inactive HBsAg carriers and HC	44
CD4⁺CD25⁺	PBT	CHB > HC	42
CD4⁺CD39⁺Foxp3⁺	PBT	AsC > ACLF, CHB and HC	56
CD4⁺CD25⁺Foxp3⁺	IHT	CHB > HC and resolved HBV	57
CD4⁺CD25⁺Foxp3⁺	IHT	AsC > HC and resolved HBV	57
CD4⁺CD25⁺Foxp3⁺	PBT	AHB > CHB > HC	27
CD4⁺CD25^high	PBT	CHB > AHB and HC	9
CD4⁺CD127^low CD25^hi-int	PBT	CHB > HC	58, 59
CD4⁺CD25⁺	PBT	CHB > HC	60, 61
CD4⁺CD25^high	PBT	CHB > AHB and HC	28, 30, 62
CD4⁺CD25^high CTLA-4⁺	PBT	CHB = HC	63
CD4⁺CD25⁺	PBT	CHB = HC	64

Tregs: regulatory T-cells; HBV: hepatitis B virus; HC: healthy control; CD: cluster of differentiation; Foxp3: forkhead box protein 3; PBT: peripheral blood Tregs; IHT: intrahepatic Tregs; ACLF: acute-on-chronic liver failure; AsC: asymptomatic carriers; CHB: chronic hepatitis B; TIT: tumor infiltrating Tregs; AHB: acute hepatitis B; CTLA-4: cytotoxic T-lymphocyte antigen-4; >: significantly higher; <: significantly lower; =: no significant difference.