. 2016 Nov 9;2(2):67–80. doi: 10.1016/j.cdtm.2016.09.001

Table 3.

Relationships between Tregs and clinicopathological features of HBV-related diseases.

Markers of Tregs	Tregs positions	Classes	Clinicopathologic features	Relation	References
CD4⁺Foxp3⁺	TIT	HCC	Liver cirrhosis	(+)	47
CD4⁺CD25⁺	TIT	HCC	Tumor size	(+)	47, 56
CD4⁺Foxp3⁺	TIT	HCC	Poorer differentiation	(+)	53, 88
CD4⁺CD25⁺CD127⁻	PBT	HCC	Decreased circulating leukocytes and ferritin; portal vein thrombosis, heptic vein involvement; advanced clinical stages evaluated by TNM or BCLC scores	(+)	72
CD4⁺CD25⁺Foxp3⁺	TIT	HCC	Preoperative serum AFP level	(+)	117
CD4⁺Foxp3⁺	TIT	HCC	Absence of tumor encapsulation;	(+)	118
CD4⁺Foxp3⁺	TIT	HCC	presence of tumor vascular invasion	(+)	118
CD4⁺CD25⁺Foxp3⁺	PBT	HBeAg⁺ CHB	HBV DNA load	(+)	11
CD4⁺CD25⁺Foxp3⁺	PBT	CHB and AsC	HBV DNA load	(+)	105
CD4⁺CD25⁺	PBT	ACLF	HBV DNA load	(+)	36, 67
			Serumal IL-10	(+)
			INR	(+)
			MELD score	(+)
CD4⁺Foxp3⁺	PBT	CHB	HBsAg	(+)	38
CD4⁺CD45RA⁻Foxp3^high	PBT	CAH	HBV DNA load	(+)	61
CD4⁺CD45RA⁻Foxp3^low	PBT	CAH	HAI score	(+)	61
CD4⁺CD25⁺Foxp3⁺	PBT	CHB	Serum ALT, HBsAg, HBeAg	(+)	30
CD4⁺CD25^high	PBT	CHB	HBV DNA load	(+)	30, 67, 95
CD4⁺CD39⁺Foxp3⁺	PBT	AsC	HBV DNA load	(+)	70
CD4⁺CD39⁺Foxp3⁺	PBT	AsC	Serum ALT	(−)	70
CD4⁺CD25^high	PBT	CHB	HBV DNA load	(+)	119
CD4⁺CD25^high	PBT	CHB	HBeAg	No	119
CD4⁺Foxp3⁺IL-10⁺	PBT	CHB	HBV DNA load	(+)	106
CD4⁺CD25⁺	PBT	CHB	HBV DNA load	(+)	28

Tregs: regulatory T-cells; HBV: hepatitis B virus; CD: cluster of differentiation; Foxp3: forkhead box protein 3; TIT: tumor infiltrating Tregs; HCC: hepatocellular carcinoma; PBT: peripheral blood Tregs; TNM: Tumor-Node-Metastasis; BCLC: Barcelona Clinic Liver Cancer; AFP: Alpha fetal protein; HBeAg: Hepatitis B envelope antigen; CHB: chronic hepatitis B; DNA: deoxyribonucleic acid; AsC: asymptomatic carriers; ACLF: acute-on-chronic liver failure; IL-10: interleukin-10; INR: international normalized ratio; MELD: Model for end stage liver disease; HBsAg: hepatitis B surface antigen; CAH: chronic active hepatitis; HAI: histological activity index; ALT: alanine aminotransferase; (+): positively correlated; (−): negatively correlated; No: no correlation.