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. 2017 Oct 12;8:709. doi: 10.3389/fphar.2017.00709

FIGURE 1.

FIGURE 1

Chemical structure and in vitro affinities of the non-imidazole H3R antagonist/inverse agonist E159. a [125I]Iodoproxyfan binding assay at human H3Rstably expressed in CHO-K1 cells, n = 3 (Ligneau et al., 1994; Ligneau et al., 2000; Lazewska et al., 2006). b [3H]Histamine binding assay performed with cell membrane preparation of Sf9 cells transiently expressing the human histamine H4Rand co-expressed with Gαi2 and Gβ1γ2 subunits, n = 3 (Meier et al., 2001; Amon et al., 2007; Isensee et al., 2009; Tomasch et al., 2013). c [3H]Pyrilamine binding assay performed with cell membrane preparation of CHO-hH1Rcells stably expressing the human H1R, n = 3 (Schibli and Schubiger, 2002; van Staveren and Metzler-Nolte, 2004; Schlotter et al., 2005).