FIGURE 4.
Effect of vehicle, E159, ZOL, and SCO on DIZ-induced deficit in an inhibitory avoidance conditioned response in rats. Gray columns represent the mean STLs measured during the retention test (test latencies) and black columns the mean STLs measured during the training trial before the delivery of the foot-shock (pre-shock latencies). Rats were injected with E159 (2.5 mg/kg, i.p.), ZOL (10 mg/kg, i.p.), SCO (1 mg/kg, i.p.) or a combination of ZOL (10 mg/kg) + SCO (1 mg/kg) 30–45 min before the test session. $P < 0.001 for mean STLs vs. the value of the (Saline)-treated group. ∗∗P < 0.001 for mean STLs vs. the value of the (DIZ)-treated group. #P < 0.05 for mean STLs vs. the value of the (DIZ + E159 + ZOL)- and (DIZ + E159 + SCO)-treated group vs. the value of the (DIZ)-treated group. Data are expressed as mean ± SEM (n = 7).