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. 2017 Oct 12;8:709. doi: 10.3389/fphar.2017.00709

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Copyright © 2017 Alachkar, Łażewska, Kieć-Kononowicz and Sadek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of E159 on DIZ-induced LTM cognitive deficits in the object recognition test in rats. Thirty minutes following training session T1, E159 (2.5 mg/kg), DOZ (1 mg/kg), or DIZ (0.1 mg/kg) was administrated intraperitoneally. The test session T2 was performed 24 h (LTM) after the training session T1 in which E159 (2.5 mg/kg) was administered 30–45 min before T2. Results are calculated as individual percentage of time spent exploring familiar (black columns) and novel (gray columns) objects. Data represent mean ± SEM of 6–8 animals per experimental group. ^∗∗∗P < 0.001 vs. respective familiar object.