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. 2017 Oct 12;8:709. doi: 10.3389/fphar.2017.00709

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Copyright © 2017 Alachkar, Łażewska, Kieć-Kononowicz and Sadek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of acute E159 pretreatment on exploratory behavior in the EPM test. E159 (0 or 2.5 mg/kg) did not change the percentage of time spent on the open arms of the EPM (A), the number of entries into the open arms (B), and the percentage of entries into the open arms (C). Pretreatment with the H3R antagonist/inverse agonist E159 did not affect the number of closed arm entries (D). However, DZP significantly increased the percentage of time spent on the open arms of the EPM (A), increased the number of entries into the open arms (B) and the percentage of entries into the open arms (C), without significant alteration in the number of closed arm entries (D). Data are expressed as mean ± SEM (n = 8–10). ^∗P < 0.05 for the value of DZP-treated group vs. the value of the E159 (Saline)- or (2.5 mg)-treated group.