Table 1. Polygenetic risk scores for intraocular pressure (IOP), diastolic blood pressure (DBP) and the combined ocular perfusion pressure (OPP) panels in relation to primary open-angle glaucoma (POAG; n=3 853 cases) and its high-tension glaucoma (HTG; n=1 774 cases) and normal tension glaucoma (NTG; n=725 cases) subtypes in the NEIGHBORHOOD consortium (n=37 333).
| Association studied | Odds Ratio | 95% lower bound | 95% upper bound | P-value |
|---|---|---|---|---|
| IOP SNPs–POAG | 1.18 | 1.14 | 1.21 | 1.8 × 10−27 |
| DBP SNPs–POAG | 1 | 0.98 | 1.01 | 0.93 |
| OPP SNPs–POAG | 1.04 | 1.02 | 1.05 | 7.4 × 10−7 |
| IOP SNPs–HTG | 1.2 | 1.15 | 1.25 | 1.1 × 10−20 |
| DBP DBP–HTG | 1 | 0.98 | 1.02 | 0.97 |
| OPP SNPs–HTG | 1.04 | 1.02 | 1.06 | 1.6 × 10−5 |
| IOP SNPs–NTG | 1.18 | 1.12 | 1.25 | 6.2 × 10−9 |
| DBP SNPs–NTG | 1 | 0.97 | 1.03 | 0.96 |
| OPP SNPs–NTG | 1.04 | 1.01 | 1.07 | 0.0061 |
Abbreviation: SNPs, single-nucleotide polymorphisms. NB: DBP allele variants coded as allele associated with lower diastolic blood pressure and IOP allele variants coded as allele with higher intraocular pressure so as to mimic the OPP term. Polygenetic risk scores are unweighted. Bold values represent p-values<0.05.