Fig. 4. Serum stability and membrane disruptive properties of AMBPs. (a) Stability assay in human serum. AMBPs were incubated at 200 μM at 37 °C. The decrease of the peptide peak was followed by LC/MS. (b) Fluorescein leakage assay from PG vesicles with 62b. (c) Fluorescence intensity upon treatment of fluorescein loaded PG vesicles with 5 μg mL–1, t = 150 s, for the indicated AMBPs. (d) TEM images of P. aeruginosa cells treated with AMPs.
